Drug intelligence / Profile preview

thc cannabis extract

Development stage: Unknown
Lead developer: Johns Hopkins University
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

THC cannabis extract is a Δ9-tetrahydrocannabinol (Δ9-THC)-dominant natural botanical extract derived from the *Cannabis sativa* plant. Unlike purified pharmaceutical cannabinoids such as dronabinol, this whole-plant extract is supplied by the National Institute on Drug Abuse (NIDA) Drug Supply Program for research purposes. It is primarily used as an investigational tool to evaluate the pharmacokinetic profile and potential drug-drug interactions of cannabis. In clinical studies led by Johns Hopkins University (NCT04201197), the extract is administered orally to assess its inhibitory effects on various hepatic cytochrome P450 (CYP450) enzymes, including CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A. The primary biological activity is mediated through the agonism of cannabinoid receptors CB1 and CB2.

Other names: Δ9-THC-dominant natural cannabis extractTHC-only extractdelta-9-tetrahydrocannabinol cannabis extractdelta9-tetrahydrocannabinol cannabis extractdelta 9-tetrahydrocannabinol cannabis extract

Targets

CYP2C19 (Cytochrome P450 2C19)CYP1A2 (Cytochrome P450 1A2)CNR1 (Cannabinoid receptor 1)CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)

Beyond the preview

Go deeper on thc cannabis extract.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on thc cannabis extract.

Explore the full profile