Drug intelligence / Profile preview

the First Affiliated Hospital of Zhengzhou Univ. Rap1b compound complex-1

Development stage
Preclinical
Lead developer
The First Affiliated Hospital of Zhengzhou University
01

Overview

the First Affiliated Hospital of Zhengzhou Univ. Rap1b compound complex-1: sourced facts only. name: "Complex-1, as the first Pt(IV) complex that can strongly inhibit Rap1b, is also worthy of further in-depth study." [PMID:38643568]; target: "Complex-1, as the first Pt(IV) complex that can strongly inhibit Rap1b, is also worthy of further in-depth study." [PMID:38643568]; developer: "Department of Thoracic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, PR China." [PMID:38643568]; stage: "Significantly, complex-1 also exhibited strong ability to reversal cisplatin-induced cancer cell resistance and inhibit tumor growth in TE6/cDDP xenograft mice models, with a tumor growth inhibition rate of 73.3 % at 13 mg/kg and did not show significant systemic toxicity." [PMID:38643568]

02

Targets

RAP1

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