Drug intelligence / Profile preview

ThermaFix

Development stage
Unknown
Lead developer
Edwards Lifesciences
Modality
Small Molecules, Device-based Delivery → Drug Delivery Systems
01

Overview

ThermaFix is a non-specific trade name primarily associated with two distinct product categories: medical immobilization devices used in radiation oncology and thermogenic dietary supplements marketed for weight loss. In the clinical setting, ThermaFix (manufactured by Bionix) refers to a thermoplastic immobilization system designed to maintain precise and reproducible patient positioning during radiotherapy, thereby ensuring accurate dose delivery to target tissues while minimizing exposure to healthy anatomy. In the consumer health market, ThermaFix is a brand name for various multi-ingredient dietary supplements. These formulations typically function as thermogenic agents, utilizing a blend of ingredients such as caffeine, green tea extract (rich in epigallocatechin gallate), and capsaicin. The pharmacological mechanism of these supplements involves the stimulation of the sympathetic nervous system, antagonism of adenosine receptors, and inhibition of phosphodiesterase, which collectively promote lipolysis and increase basal metabolic rate. ThermaFix is not an FDA-approved pharmaceutical drug for the treatment of any primary clinical indication.

Brand names
ThermaFix
02

Targets

COMT (Catechol-O-methyltransferase)TRPV1 (Transient receptor potential cation channel subfamily V member 1)ADOR (Adenosine receptors)PDE (Phosphodiesterase family)

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