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Thermella
- Development stage
- Unknown
- Lead developer
- Bonafide Health
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Thermella (VMS-BH02) is a nonhormonal, botanical dietary supplement developed by Bonafide Health (an indirect subsidiary of Otsuka Pharmaceutical) for the management of menopausal vasomotor symptoms (VMS), such as hot flashes and night sweats. It is formulated as a proprietary blend of curcumin extract (specifically Longvida optimized curcumin extract), decaffeinated green tea extract, and spirulina extract. Thermella acts as a neurokinin 3 receptor (NK3R) antagonist, blocking the neurokinin B (NKB) pathway to restore balance to the body's thermoregulatory center in the hypothalamus. It is marketed as a hormone-free, prescription-free alternative to hormone replacement therapy and prescription NK3R antagonists.
- Brand names
- Thermella
- Other names
- curcumin + decaffeinated green tea extract + spirulina extractcurcumin + green tea + spirulinacurcumin + green tea extract + spirulina extract
02
Targets
TACR3 (Neurokinin 3 Receptor)
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