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Senegalia berlandieri extract, primarily marketed under the brand name Thermo-Rx®, is a botanical dietary supplement ingredient used for weight management and energy enhancement. Developed and marketed by Hi-Tech Pharmaceuticals, the extract is standardized to 95% phenylethylamine alkaloids, including N-methylphenethylamine, tyramine, and phenethylamine. These compounds function as sympathomimetic amines that stimulate the central nervous system and metabolism by increasing the activity of catecholamines such as dopamine, adrenaline, and noradrenaline. It is frequently included in multi-ingredient weight loss formulations as an alternative to ephedra or DMAA. The extract is claimed to increase metabolic rate significantly shortly after ingestion, though its use has been subject to regulatory scrutiny regarding the natural versus synthetic origin of its constituent alkaloids.
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