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THH-FMT

Development stage: Preclinical
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral, Rectal

Overview

THH-FMT is an experimental microbial therapy consisting of fecal microbiota transplantation (FMT) derived from donors treated with *Tripterygium hypoglaucum* (H. Lév.) Hutch. (THH). THH is a botanical extract used in traditional Chinese medicine for its anti-inflammatory and immunosuppressive properties, particularly in the treatment of autoimmune conditions such as psoriasis. THH-FMT is utilized in preclinical research to investigate the role of the gut microbiota-metabolite axis in the therapeutic efficacy of THH. By transferring the THH-altered microbiome to recipient models, the treatment aims to suppress inflammatory responses, modulate the gut-skin axis, and ameliorate psoriasis-like dermatitis, highlighting the potential of microbiome-targeted strategies in managing inflammatory skin diseases.

Other names: Tripterygium hypoglaucum-modulated fecal microbiota transplantation

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