thiacremonone

Thiacremonone is a **novel sulfur-containing small molecule** derived from high-temperature, high-pressure-treated *garlic* (Allium sativum) and found in some fungi. It exerts **antioxidant**, **anti-inflammatory**, and **anticancer** effects. Mechanistically, it inhibits the enzymatic activity of glutathione peroxidase of **peroxiredoxin 6 (PRDX6)** leading to apoptosis in cancer cells. Thiacremonone also inhibits other enzymes such as **angiotensin-converting enzyme (ACE)**, **xanthine oxidase (XO)**, and **tyrosinase** but with lower potency than established inhibitors. In various preclinical models, it shows inhibition of tumor growth (notably in lung and colon cancer models), reduction of inflammatory markers, and attenuation of oxidative stress. It has *no significant cytotoxicity in normal cells*. Development has been preclinical, and no major pharmaceutical developer appears associated.

Other names

2,4-dihydroxy-2,5-dimethylthiophen-3-one2,4-dihydroxy-2,5-dimethyl-3(2H)-thiophenone2,4-dihydroxy-2,5-dimethyl-2,3-dihydrothiophen-3-one2,4-dihydroxy-2,5-dimethylthiophen-3(2H)-one2,5-dimethyl-2,4-dihydroxy-3(2H)-thiophenone96504-28-8