Drug intelligence / Profile preview

thiamidol

Development stage
Phase 2
Lead developer
Beiersdorf
Modality
Small Molecules
Administration
Topical
01

Overview

**Thiamidol** is a proprietary, patented active ingredient developed by Beiersdorf, primarily used in skincare for the treatment of hyperpigmentation disorders, including melasma, solar lentigines, and post-inflammatory hyperpigmentation. It acts as a potent, reversible inhibitor of human tyrosinase, an enzyme critical in the synthesis of melanin, thereby reducing the formation and accumulation of pigment spots. Thiamidol has shown superior efficacy when compared to traditional agents like hydroquinone, with notable reductions in MASI scores and high rates of patient improvement[1][3][4][9]. Its safety profile is suitable for long-term, over-the-counter use, with minimal adverse effects, making it appropriate for sensitive and diverse skin types[1][3][7].

Brand names
Eucerin Anti-Pigment Dual SerumNivea Cellular Luminous 630
Other names
isobutylamido thiazolyl resorcinol4-butylresorcinol
02

Targets

TYR (Tyrosinase)

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