thiamine + biotin

Thiamine + biotin is a combination of two water-soluble B vitamins, thiamine (vitamin B1) and biotin (vitamin B7). Thiamine acts as an essential cofactor in carbohydrate metabolism and energy production, playing a critical role in the function of the nervous system. Biotin functions as a coenzyme for carboxylase enzymes involved in fatty acid synthesis, amino acid catabolism, and gluconeogenesis. The combination is used therapeutically to treat or prevent deficiencies of these vitamins due to poor diet, certain illnesses, alcoholism, or increased requirements such as during pregnancy. Notably, high-dose thiamine plus biotin supplementation is the standard treatment for biotin-thiamine-responsive basal ganglia disease (BTRBGD), a rare inherited neurological disorder caused by mutations affecting thiamine transport into cells[2][3][7]. In this context, early administration can be life-saving and may prevent irreversible neurological damage.

Other names

biotin-Fundación Pública Andaluza para la gestión de la Investigación en Sevilla-Huntington diseasecombined thiamine and biotin therapyhigh-dose thiamine and biotin