Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
thiamine + biotin
- Development stage
- Phase 2
- Lead developer
- Lydian
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral, Intravenous, Intramuscular
01
Overview
Thiamine + biotin is a combination of two water-soluble B vitamins, thiamine (vitamin B1) and biotin (vitamin B7). Thiamine acts as an essential cofactor in carbohydrate metabolism and energy production, playing a critical role in the function of the nervous system. Biotin functions as a coenzyme for carboxylase enzymes involved in fatty acid synthesis, amino acid catabolism, and gluconeogenesis. The combination is used therapeutically to treat or prevent deficiencies of these vitamins due to poor diet, certain illnesses, alcoholism, or increased requirements such as during pregnancy. Notably, high-dose thiamine plus biotin supplementation is the standard treatment for biotin-thiamine-responsive basal ganglia disease (BTRBGD), a rare inherited neurological disorder caused by mutations affecting thiamine transport into cells[2][3][7]. In this context, early administration can be life-saving and may prevent irreversible neurological damage.
- Other names
- combined thiamine and biotin therapyhigh-dose thiamine and biotin
02
Targets
ACC (Acetyl-CoA Carboxylase 1)α-KGDH (Alpha-ketoglutarate dehydrogenase complex)PCCA (Propionyl-CoA carboxylase alpha subunit)PROC (Protein C)PDHA1 (Pyruvate dehydrogenase (lipoamide) alpha 1)TKT (Transketolase)PDH (Pyruvate dehydrogenase complex)
Beyond the preview
Go deeper on thiamine + biotin.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on thiamine + biotin.