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thiamine + riboflavin + ascorbic acid + vitamin E
- Development stage
- Unknown
- Lead developer
- National Institute of Allergy and Infectious Diseases
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
This combination therapy, consisting of antioxidants (ascorbic acid and vitamin E) and B vitamins (thiamine and riboflavin), was evaluated by the National Institute of Allergy and Infectious Diseases (NIAID) in a pilot clinical study. The primary objective was to prevent the recurrence of hyperlactatemia in HIV-infected patients who were restarting nucleoside reverse transcriptase inhibitor (NRTI) therapy. Hyperlactatemia in this population is frequently associated with NRTI-induced mitochondrial toxicity. The B vitamins (B1 and B2) act as essential cofactors for mitochondrial enzymes involved in the Krebs cycle and the electron transport chain, thereby supporting cellular energy metabolism. Vitamins C and E serve as antioxidants that scavenge reactive oxygen species, potentially mitigating the oxidative stress and tissue damage caused by mitochondrial dysfunction.
- Other names
- Antioxidants and B VitaminsVitamin CVitamin EVitamin B1Vitamin B2Thiamine hydrochlorideRiboflavinAscorbic acid
02
Targets
ND1 (Mitochondrial electron transport chain complex I)OADC (Alpha-ketoacid dehydrogenase complex)SDH (Mitochondrial electron transport chain complex II)
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