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thiamine mononitrate
- Development stage
- Phase 3
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Thiamine mononitrate is a synthetic, stable salt form of thiamine (vitamin B1), an essential water-soluble vitamin. It is used as a dietary supplement and to treat or prevent vitamin B1 deficiency. Thiamine plays a critical role in carbohydrate metabolism by acting as a coenzyme for several enzymes involved in the breakdown of sugars and amino acids. It is necessary for energy production and proper functioning of the nervous system, heart, and muscles. Thiamine mononitrate is commonly found in oral supplements (tables/capsules) and fortified foods due to its stability compared to other forms of thiamine[4][5]. Deficiency can lead to conditions such as beriberi and Wernicke-Korsakoff syndrome[1][4]. The mechanism of action involves serving as a precursor for the coenzyme thiamine pyrophosphate (TPP), which is essential for enzymatic reactions in glucose metabolism.
- Brand names
- Vitamin B1
- Other names
- thiaminevitamin B1thiaminaneurinantiberiberi factor
02
Targets
PDH (Pyruvate dehydrogenase complex)TKT (Transketolase)α-KGDH (Alpha-ketoglutarate dehydrogenase complex)
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