Drug intelligence / Profile preview

thiamine nitrate

Development stage
Phase 4
Modality
Small Molecules
Administration
Oral, Intravenous, Intramuscular
01

Overview

Thiamine nitrate is a water-soluble form of **vitamin B1** used as a pharmaceutical and dietary supplement, distinct from thiamine hydrochloride and thiamine mononitrate[4]. As a member of the B vitamins, thiamine nitrate acts as an essential coenzyme in carbohydrate metabolism, facilitating conversion of sugars into energy and supporting normal nerve, muscle, and heart function[7][8]. It is typically prescribed to treat and prevent thiamine deficiency—including beriberi, Wernicke-Korsakoff syndrome, and metabolic disorders related to pyruvate dehydrogenase deficiency[4]. Its mechanism of action is primarily via its conversion into thiamine diphosphate (thiamine pyrophosphate), which serves as a coenzyme for several key enzymes involved in the Krebs cycle and pentose phosphate pathway, supporting ATP production and neural function[8]. Thiamine nitrate is mainly absorbed in the duodenum and excreted quickly if taken in excess[4][8]. Dosage forms and indications may vary depending on country regulations, but it is most often administered orally or parenterally for deficiency states[4].

Other names
thiamine nitratethiamin nitrate
02

Targets

OGDH (Dihydrolipoamide S-succinyltransferase)TKT (Transketolase)PDH E1 (Pyruvate dehydrogenase E1 component)

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