Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
thiamine pyrophosphate
- Development stage
- Unknown
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Intravenous, Intramuscular, Sublingual
01
Overview
Thiamine pyrophosphate (TPP), also known as thiamine diphosphate or cocarboxylase, is the active coenzyme form of vitamin B1 (thiamine). It is formed in the body by phosphorylation of thiamine and serves as an essential cofactor for several enzymes involved in carbohydrate metabolism, including pyruvate dehydrogenase and transketolase. TPP plays a critical role in decarboxylation reactions and the pentose phosphate pathway. Deficiency leads to impaired energy metabolism and neurological symptoms. Thiamine pyrophosphate is not typically administered directly as a drug; instead, thiamine or its salts are given, which are then converted to TPP in vivo[3][8][9].
- Brand names
- EnBrace HREnLyte
- Other names
- thiamine diphosphatecocarboxylaseTPP
02
Targets
PDH E1 (Pyruvate dehydrogenase E1 component)TPP riboswitch (Thiamine pyrophosphate riboswitch)TKT (Transketolase)
Beyond the preview
Go deeper on thiamine pyrophosphate.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on thiamine pyrophosphate.