Drug intelligence / Profile preview

thiamphenicol glycinate acetylcysteinate

Development stage
Unknown
Lead developer
Zambon Group
Modality
Small Molecules
Administration
Inhalation, Intramuscular, Oral
01

Overview

**Thiamphenicol glycinate acetylcysteinate** is a fixed small-molecule antibacterial and mucolytic product comprising thiamphenicol glycinate and N-acetylcysteine. Following administration, it provides thiamphenicol-mediated inhibition of bacterial protein synthesis through the bacterial 50S ribosomal subunit, while acetylcysteine reduces mucus viscosity by disrupting disulfide bonds in airway mucus glycoproteins. It has been marketed by Zambon as Fluimucil products for respiratory tract infections, including upper-airway infections, acute bronchitis, chronic bronchitis, and exacerbations of chronic obstructive pulmonary disease, with intramuscular, inhaled, and oral product presentations reported. ([journals.sagepub.com](https://journals.sagepub.com/doi/pdf/10.1177/039463200702000319))

Brand names
FluimucilFluimucil AntibioticFluimucil AntibioticoFluimucil-Antibiotic IT
Other names
N-acetyl-L-cysteine, compound with thiamphenicol glycinateTGAthiamphenicol glycinate acetylcysteinethiamphenicol glycinate acetylcisteinatethiamphenicol glycinate N-acetylcysteinate
02

Targets

Bacterial 50S ribosomal subunitAirway mucus disulfide bondsMitoribosome (Mitochondrial ribosome)

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