thio-atpa

THIO-ATPA is a synthetic small molecule and a sulfur-containing analog of ATP, specifically designed as a potent and selective agonist for kainate-type ionotropic glutamate receptors, particularly the GluR5 (now known as GluK1) subunit. It is used primarily in neuropharmacological research to study excitatory neurotransmission and receptor kinetics. The compound acts by binding to the ligand-binding domain of kainate receptors, inducing channel opening and promoting calcium influx into neurons, which is critical for synaptic plasticity and signal transduction. Structural studies have shown that (S)-thio-ATPA interacts with the GluR2/GluK1 receptor core, providing insights into agonist-specific activation mechanisms[6][8]. Its high potency makes it valuable for dissecting glutamatergic signaling pathways.

Other names

(S)-thio-ATPA3-(5-tert-butylisoxazol-3-yl)-2-thioxoimidazolidin-4-one