Thiocitrulline

Thiocitrulline is a compound that has been investigated for its biological activities. A specific derivative, S-methyl-L-thiocitrulline (SMTC), functions as a selective inhibitor of neuronal nitric oxide synthase (nNOS), an enzyme crucial for nitric oxide production. SMTC has been widely utilized in research to elucidate the physiological roles of nNOS in various systems, including neurovascular regulation, cerebral blood flow, cardiac contractility, and blood pressure control, and its involvement in conditions such as hypertension and mental stress-induced vasodilation. Additionally, thiocitrulline itself has been studied for its binding capabilities to the SARS-CoV-2 main protease, suggesting a potential role as a supplement in the treatment of SARS-CoV-2.