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thioctic acid (Innventa Pharm)
- Development stage
- Unknown
- Lead developer
- INNventa Pharm
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
R-Lipoinn is a dietary supplement containing the R-enantiomer of alpha-lipoic acid (thioctic acid), marketed by INNventa Pharm. As the naturally occurring isomer, R-alpha-lipoic acid is often cited for its superior bioavailability and biological activity compared to the synthetic racemic mixture. It functions as a potent antioxidant and an essential mitochondrial cofactor for enzyme complexes involved in energy metabolism, such as pyruvate dehydrogenase. R-Lipoinn is primarily indicated for the management of peripheral neuropathies, including diabetic and alcoholic neuropathy, as well as radiculopathies such as sciatica and carpal tunnel syndrome, aiming to alleviate oxidative stress and support nerve health.
- Brand names
- R-Lipoinn
- Other names
- R-alpha-lipoic acidR-thioctic acidalpha-lipoic acid
02
Targets
PDK (Pyruvate dehydrogenase kinase isoform 1)DBT (Branched-chain alpha-keto acid dehydrogenase E2 component)DLD (Dihydrolipoamide dehydrogenase)DLAT (Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex)DLST (Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial)
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