thiolactomycin

Thiolactomycin is a naturally occurring antibiotic isolated from Streptomyces and Nocardia species. It is a small molecule with the molecular formula C11H14O2S and a molecular weight of approximately 210.29 g/mol. Thiolactomycin acts as an inhibitor of bacterial type II fatty acid synthase (FAS-II), specifically targeting β-ketoacyl-acyl carrier protein synthases (KAS). By inhibiting these enzymes, thiolactomycin disrupts fatty acid biosynthesis in bacteria—a pathway distinct from that in mammals—making it of interest as an antibacterial agent against pathogens such as Mycobacterium tuberculosis. It has not been approved for clinical use and remains primarily an experimental compound studied for its mechanism and potential applications in antibacterial drug development[1][3][5].

Other names

4-Hydroxy-3,5-Dimethyl-5-(2-Methyl-Buta-1,3-Dienyl)-5h-Thiophen-2-One(5R)-4-hydroxy-3,5-dimethyl-5-(2-methylbuta-1,3-dienyl)-2,5-dihydrothiophen-2-one(R)-(+)-Thiolactomycin(+)-ThiolactomycinAntibiotic 2–20082079–32–1