thiolutin

**Thiolutin** is a dithiolopyrrolone and sulfur-containing antibiotic synthesized by various *Streptomyces* species, notably *Streptomyces luteosporeus*[1][10]. It displays broad-spectrum antibacterial and some antifungal activity, along with notable anti-angiogenic effects[1][3][10]. Thiolutin acts as a potent, reversible inhibitor of bacterial and yeast DNA-dependent RNA polymerases (types I, II, and III), thereby blocking RNA synthesis (transcription)[1][3][5][9][10]. It is also reported to inhibit certain JAMM domain zinc metalloproteases (e.g., Rpn11, Csn5, AMSH, Brcc36)[2][7], act as a zinc chelator, and disrupt cellular processes like mRNA degradation and cytoskeletal organization (via Hsp27 perturbation), which leads to the inhibition of endothelial cell adhesion and angiogenesis[1][2][3][6][7]. Thiolutin is primarily used as a research tool, including in the study of mRNA synthesis and stability, not as a human therapeutic agent[4][6][9]. Its effects are reversible, making it valued in experimental modulation of transcription[5].

Other names

acetopyrrothinacetopyrrothinepropiopyvothinefarcinicin