thiomyristoyl

Thiomyristoyl is a potent, cell-permeable, and selective small molecule inhibitor of **Sirtuin 2 (SIRT2)**. Originally identified for its extensive anticancer activity, it works by inhibiting SIRT2-mediated deacetylation and demyristoylation of various protein substrates. Beyond oncology, thiomyristoyl has demonstrated significant anti-inflammatory properties in preclinical models. Specifically, it has been shown to ameliorate experimental colitis by blocking the differentiation of **Th17 cells**, a process mediated through the inhibition of the **STAT3/IL-6** signaling pathway. By modulating the acetylation status of key immune regulators, thiomyristoyl represents a potential therapeutic candidate for inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis.

Other names

thiomyristoyl-lysineN6-(1-thiotetradecanoyl)-L-lysine