Drug intelligence / Profile preview

thiopental + propofol

Development stage
Phase 2
Lead developer
Abbott
Modality
Small Molecules
Administration
Intravenous
01

Overview

Thiopental and propofol are two separate intravenous anesthetic agents that may be used together in anesthesia practice. This is not a fixed-dose combination product but rather represents the concurrent or sequential use of both medications. **Thiopental** is a rapid-onset short-acting barbiturate that decreases cerebral metabolic oxygen requirements and cerebral blood flow. It has been traditionally used for induction of anesthesia and management of increased intracranial pressure. **Propofol** is a sedative-hypnotic agent that has largely replaced thiopental for induction of general anesthesia. It is known for its rapid recovery profile and fewer post-anesthetic side effects. When used together, these agents may complement each other's effects or be administered at different points during anesthesia management. The combination might be employed to achieve specific hemodynamic goals or to reduce the dose requirements of either agent alone.

Other names
thiopental sodium + propofolthiopentone + propofol
02

Targets

SCN2A (Voltage-gated sodium channel protein type 2 subunit alpha)SCN4A (Voltage-gated sodium channel protein type 4 subunit alpha)GABA-B (Gamma-aminobutyric acid receptor type B)GABRB2 (GABA-A receptor subunit beta-2)GABRB3 (GABA-A receptor subunit beta-3)

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