Drug intelligence / Profile preview

thiosildenafil

Development stage
Unknown
Modality
Small Molecules
01

Overview

Thiosildenafil is a **small-molecule sildenafil analogue** in which sulfur replaces oxygen in the pyrazolopyrimidine core. It is not a legitimate approved or clinically developed pharmaceutical product; rather, it has been reported as an **undeclared adulterant** in sexual-enhancement dietary supplements and related health products. Based on its close structural relationship to sildenafil, thiosildenafil is generally understood to belong to the **phosphodiesterase-5 inhibitor analogue** family and is therefore expected to have PDE5-inhibitory pharmacology, but its human pharmacology, efficacy, toxicology, and safety have not been adequately characterized in formal development programs. It is primarily encountered as a research or analytical reference standard rather than a medicine for human use.

Other names
thiosildenafil
02

Targets

PDE5 (Phosphodiesterase 5A)

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