Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
thiothixene
- Development stage
- Approved
- Lead developer
- Pfizer
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Thiothixene is a first-generation (typical) antipsychotic medication belonging to the thioxanthene class. It is primarily indicated for the treatment of schizophrenia, both acute and chronic, and may also be used in other psychiatric disorders such as bipolar disorder, mania, and behavioral disturbances[1][4][5]. Thiothixene acts mainly by antagonizing dopamine receptors (D1, D2, D3, D4), thereby reducing abnormal excitement in the brain and balancing dopamine levels to help regulate mood, behavior, and thoughts[1][2][3][6]. It also exhibits antagonistic activity at serotonergic (5-HT1 and 5-HT2), histaminergic (H1), alpha-adrenergic (alpha1/alpha2), and muscarinic cholinergic (M1/M2) receptors[3][6]. These actions contribute to its antipsychotic effects as well as its side effect profile. The drug is administered orally; it is rapidly absorbed with peak plasma concentrations within 1–3 hours after dosing. Thiothixene was originally developed by pharmaceutical companies such as Pfizer.
- Brand names
- Navane
- Other names
- tiotixene
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))HTR2A (Serotonin receptor 5-HT2A)HTR2C (5-hydroxytryptamine 2C receptor)ADRA1A (α1A)DRD1 (Dopamine D1 Receptor)DRD2 (Dopamine D2 Receptor)DRD3 (Dopamine receptor D3)DRD4 (Dopamine D4 Receptor)HRH1 (Histamine H1 Receptor)mAChR (Muscarinic acetylcholine receptors)ADRA1 (Alpha-1 adrenergic receptor family)
Beyond the preview
Go deeper on thiothixene.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on thiothixene.