Drug intelligence / Profile preview

thioureidobutyronitrile

Development stage: Unknown
Lead developer: Innovation Pharmaceuticals
Modality: DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
Administration: Oral (po), Intravenous (iv)

Overview

Thioureidobutyronitrile (Kevetrin) is a water-soluble, small-molecule alkylating agent that acts as an activator of the tumor suppressor protein p53. It is being developed primarily as an antineoplastic (anticancer) agent. The drug’s mechanism involves stimulating apoptosis, activating caspase 3, modulating poly(ADP-ribose) polymerase and retinoblastoma protein, and directly stimulating p53 activity. Thioureidobutyronitrile has received orphan drug status for several rare cancers including retinoblastoma, pancreatic cancer, and ovarian cancer. Its highest development phase reported is Phase II for ovarian cancer[1].

Brand names: Kevetrin
Other names: thioureidobutyronitrile

Targets

PARP1 (Poly (adp-ribose) polymerase 1)CASP3 (Caspase-3)RB1 (Retinoblastoma-associated Protein)TP53 (Cellular Tumor Antigen p53 R175H)

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