Drug intelligence / Profile preview

thonzylamine

Development stage
Unknown
Modality
Small Molecules
Administration
Oral, Intranasal, Ophthalmic, Topical
01

Overview

Thonzylamine is a first-generation ethylenediamine antihistamine and anticholinergic drug used primarily in combination with other agents for the temporary relief of symptoms associated with the common cold, hay fever (allergic rhinitis), or other upper respiratory allergies. It acts as an antagonist at the Histamine H1 receptor, thereby blocking the effects of histamine that lead to symptoms such as nasal congestion, runny nose, sneezing, and itching. Thonzylamine also exhibits anticholinergic properties. As a first-generation antihistamine, it readily crosses the blood-brain barrier and may cause sedation or central nervous system side effects. It is typically found in over-the-counter combination products with agents like phenylephrine or chlophedianol for symptomatic control of allergic rhinitis and related conditions[1][3][5][6].

Brand names
NasOpen PE
Other names
thonzylamineneohetramine
02

Targets

HRH1 (Histamine H1 Receptor)M1 (Muscarinic acetylcholine receptor M1)CHRM4 (M4)CHRM3 (M3)CHRM5 (M5)CHRM2 (M2)

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