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The three-formulation traditional Chinese medicine regimen is a therapeutic protocol developed by the Affiliated Hospital of Nanjing University of Chinese Medicine (Jiangsu Province Hospital of Chinese Medicine) for the treatment of COVID-19, specifically targeting the Delta variant. The regimen is based on the Traditional Chinese Medicine (TCM) principle of syndrome differentiation and consists of three distinct herbal decoctions: Qinghuo Jiedu Decoction (for heat-toxic syndrome), Xuanfei Toujie Decoction (for lung-heat syndrome), and Yangyin Qingjie Decoction (for yin-deficiency syndrome). Patients are prescribed one of the three formulations based on their specific clinical presentation. The regimen aims to alleviate respiratory symptoms, accelerate viral clearance, and prevent progression to severe disease. It has been evaluated in multi-center randomized controlled trials in China to assess its efficacy, safety, and metagenomic mechanisms compared to control decoctions like Ganmai Dazao Decoction.
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