thrombin

Thrombin is a serine protease and a key enzyme in the blood coagulation cascade. It is produced from prothrombin (coagulation factor II) and functions by converting soluble fibrinogen into insoluble fibrin strands to form blood clots. Thrombin also activates several other coagulation factors (V, VIII, XI, XIII), promotes platelet activation and aggregation via protease-activated receptors on platelets, and has both procoagulant and anticoagulant roles depending on its interactions with cofactors such as thrombomodulin. Medically used forms of thrombin include those derived from human plasma (human thrombin), bovine sources (bovine thrombin), or produced recombinantly (recombinant human thrombin). These products are primarily used topically during surgical procedures to control bleeding when standard techniques are ineffective or impractical[1][2][3][4][8].

Brand names

Thrombin-JMIEVITHROMRecothrom

Other names

coagulation factor IIahuman thrombinbovine thrombinrecombinant human thrombin