thrombin receptor-activating peptide 6

TRAP-6 (Thrombin Receptor Activating Peptide 6) is a synthetic hexapeptide with the amino acid sequence Ser-Phe-Leu-Leu-Arg-Asn (SFLLRN). It functions as a potent and selective agonist for the Proteinase-Activated Receptor 1 (PAR1), a G protein-coupled receptor that is typically activated by thrombin. TRAP-6 works by mimicking the new N-terminal "tethered ligand" that is exposed when thrombin cleaves the PAR1 receptor. Because it does not require enzymatic cleavage to activate the receptor, it is a valuable pharmacological tool in research for investigating PAR1-mediated pathways in platelet aggregation, inflammation, and pain signaling. In clinical diagnostics, TRAP-6 is utilized in ex vivo platelet function assays, such as the Multiplate TRAPtest, to assess the responsiveness of the PAR1 pathway. Recent research has also highlighted its role in mediating visceral pain and nociceptor activation in models of colitis.

Other names

SFLLRN peptideThrombin receptor agonist peptidePAR1 agonist peptidePAR-1 agonist peptidePAR 1 agonist peptide