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Thrombostim
- Development stage
- Phase 3
- Lead developer
- South African National Blood Service
- Modality
- Other Cell Types → Cell Therapies, Blood Coagulation Factors → Therapeutic Enzymes → Recombinant Proteins and Enzymes
- Administration
- Topical
01
Overview
**Thrombostim** is a topical, dual-component, human blood-derived wound-healing product developed and manufactured by the South African National Blood Service. It contains lyophilized platelet-rich plasma and lyophilized human thrombin, which are reconstituted and combined at application to form a fibrin-rich coagulum. The thrombin component converts fibrinogen to fibrin and helps generate a local clot matrix, while platelet-rich plasma supplies platelet-derived growth factor and other platelet-associated mediators intended to support tissue repair. It has been evaluated in a Phase 3 study for recalcitrant venous stasis ulcers.
- Brand names
- Thrombostim
- Other names
- PRP/thrombin mixturePlatelet Rich Plasma and Thrombin Coagulumtopical Platelet Rich Plasma and Thrombin mixture
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