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thunbergia laurifolia leaf extract
- Development stage
- Preclinical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
*Thunbergia laurifolia* leaf extract (TLL), derived from the Thai medicinal plant known as Rang Chuet, is a botanical extract traditionally used for the detoxification of poisons. Recent research has explored its potential therapeutic applications in treating cognitive dysfunction and depression-like behaviors. Preclinical studies in olfactory bulbectomized (OBX) mice have demonstrated that TLL can ameliorate non-spatial short-term memory deficits and exhibit antidepressant-like actions. Its mechanism of action is linked to the modulation of the cholinergic system, specifically by reversing the down-regulation of choline acetyltransferase (ChAT) and muscarinic M1 receptor expression in the hippocampus, which are often compromised in neurodegenerative conditions like Alzheimer's disease.
- Other names
- Thunbergia laurifolia Lindl. leaf extractRang Chuet leaf extract
02
Targets
CHAT (Choline acetyltransferase)M1 (Muscarinic acetylcholine receptor M1)
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