Thy1 single-chain variable fragment

**Thy1 single-chain variable fragment (Thy1-scFv)** is a recombinant antibody fragment that specifically targets the thymocyte differentiation antigen 1 (Thy1/CD90), a cell-surface glycoprotein overexpressed in the neovasculature of various cancers, notably pancreatic ductal adenocarcinoma (PDAC)[1]. This molecule is engineered as a single-chain variable fragment (scFv), combining the variable regions of the heavy and light chains of an antibody into a single polypeptide via a flexible linker. Thy1-scFv retains high binding specificity to Thy1, enabling its use in molecular imaging for early cancer diagnosis, particularly for PDAC, where over 80% of cases show Thy1 upregulation in tumor vasculature[1][2][4]. It is typically produced via recombinant expression in *E. coli*, and it can be conjugated to imaging agents, such as ultrasound contrast microbubbles, to enable targeted detection of tumors in vivo[1].

Other names

Thy1-scFvThy-1-scFvThy 1-scFv