thymoglobulin + prednisone + everolimus + tacrolimus

This is a combination immunosuppressive regimen commonly used in solid organ transplantation, particularly kidney transplantation. The regimen includes: **Thymoglobulin (anti-thymocyte globulin [rabbit])**: A polyclonal antibody preparation that depletes T lymphocytes by targeting multiple surface antigens, leading to profound immunosuppression. It is primarily used for induction therapy and treatment of acute rejection in transplant recipients[1][2][4]. **Prednisone**: A synthetic glucocorticoid corticosteroid with potent anti-inflammatory and immunosuppressive properties. It acts by modulating gene expression to suppress immune responses. **Everolimus**: An mTOR inhibitor that blocks the mammalian target of rapamycin pathway, inhibiting lymphocyte activation and proliferation. Everolimus also has antiproliferative effects on smooth muscle cells and tumor cells[6]. **Tacrolimus**: A calcineurin inhibitor that suppresses T-cell activation by inhibiting interleukin 2 (IL-2) transcription. Together, these agents provide multi-modal suppression of the immune system to prevent or treat organ rejection after transplantation.

Other names

anti-thymocyte globulin rabbitantithymocyte globulin rabbit