Drug intelligence / Profile preview

thymoject + fumaric acid + selenase

Development stage
Preclinical
Lead developer
Biosyn
Modality
Small Molecules, Peptides
Administration
Intravenous, Oral
01

Overview

"Thymoject + fumaric acid + selenase" is an investigational combination therapy that has been studied for the treatment of psoriasis. The regimen combines Thymoject (an intravenous thymus extract), fumaric acid, and Selenase (an intravenous selenium preparation, specifically sodium selenite). The therapeutic rationale is based on the synergistic immunomodulatory effects of its components to address the underlying immunological basis of psoriasis. Fumaric acid esters are known to be an effective treatment for psoriasis. Thymus extracts contain peptides that regulate immune function, and have been explored in various immune-related conditions, including psoriasis. Selenium is an essential trace element with antioxidant properties. The combination was evaluated in a study of 54 patients, where it reportedly demonstrated a faster healing rate compared to treatment with fumaric acid alone.

02

Targets

FH (Fumarate hydratase)TLR2 (Toll-like Receptor 2)SELENOS (Selenoprotein S)GPX4 (Glutathione peroxidase 4)NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)

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