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Thymus vulgaris
- Development stage
- Unknown
- Lead developer
- University of Sulaimani
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Buccal, Topical
01
Overview
Thymus vulgaris (common thyme) is a botanical extract evaluated as an active ingredient in herbal mouthwash formulations for the management of biofilm-induced gingivitis. It contains bioactive compounds, such as thymol and carvacrol, which exhibit potent antibacterial, anti-inflammatory, and antioxidant properties. In clinical studies, Thymus vulgaris mouthwash has been shown to reduce plaque accumulation, gingival bleeding, and salivary levels of inflammatory mediators (such as interleukin-1 beta and matrix metalloproteinase-8), offering a natural alternative to chemical plaque control agents like chlorhexidine.
- Other names
- thymethyme essential oilthyme extractthyme oilThymus vulgaris essential oilThymus vulgaris extract
02
Targets
ABCG2 (Breast cancer resistance protein)AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)CrtM (Dehydrosqualene synthase)EGFR (Epidermal growth factor receptor)ESR1 (ERα)HSPA5 (Heat shock protein family A member 5)MMP12 (Macrophage Metalloelastase)PGHS-1 (Prostaglandin G/H Synthase 1)TGFB1 (Transforming growth factor Beta-1 proprotein)
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