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thyroid, desiccated
- Development stage
- Unknown
- Lead developer
- Acella Pharmaceuticals
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Oral
01
Overview
Desiccated porcine thyroid extract (DTE) is a biological product derived from the dried thyroid glands of pigs (*Sus scrofa*). It is used as a hormone replacement therapy for patients with hypothyroidism. Unlike synthetic levothyroxine (T4), DTE contains a combination of both T4 and liothyronine (T3), typically in a ratio of approximately 4:1, along with other thyroid-related proteins and iodine. It acts by binding to thyroid hormone receptors in the nucleus of target cells, regulating gene expression and metabolic processes. Neuvosyn Laboratories is developing a specific formulation referred to as North Star for the treatment of primary hypothyroidism, which is currently in Phase 3 clinical evaluation.
- Brand names
- North StarArmour ThyroidNP ThyroidNature-ThroidWP Thyroid
- Other names
- desiccated porcine thyroid extractporcine thyroid extractnatural desiccated thyroidNDTDTE
02
Targets
αVβ3 (Integrin αVβ3)THRB (Thyroid hormone receptor beta)THRA (Thyroid hormone receptor alpha)TTR (Transthyretin)
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