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thyroxine + aspirin + selenium + calcium + vitamin D
- Development stage
- Unknown
- Lead developer
- Al Jazeera Hospital
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
This combination regimen is a specific treatment protocol investigated by Aljazeera Hospital for the management of infertility in women with autoimmune thyroiditis. The regimen consists of thyroxine, low-dose aspirin, low-dose selenium, calcium, and vitamin D. Thyroxine is administered to maintain euthyroidism, while low-dose aspirin is used to potentially enhance uterine blood flow and reduce inflammation. The protocol also includes nutritional supplementation with selenium, which may reduce thyroid autoantibody levels, and calcium/vitamin D to support overall metabolic and reproductive health. In clinical trial settings, this combination has served as a baseline or control arm to evaluate the efficacy of additional immunomodulatory treatments (such as prednisolone and hydroxychloroquine) in improving the success rates of Intracytoplasmic Sperm Injection (ICSI) and In Vitro Fertilization-Embryo Transfer (IVF-ET).
- Other names
- Thyroxine intervention arm
02
Targets
αVβ3 (Integrin αVβ3)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)VDR (Vitamin D receptor)THRB (Thyroid hormone receptor beta)PGHS-1 (Prostaglandin G/H Synthase 1)
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