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TI-0010
- Development stage
- Phase 1
- Lead developer
- Therorna
- Modality
- Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intramuscular
01
Overview
TI-0010 is a novel lipid nanoparticles (LNP)-encapsulated circular RNA (circRNA)-based vaccine targeting the receptor-binding domain (RBD) of SARS-CoV-2. It is being developed as an intramuscular vaccine for the prevention of COVID-19. The circRNA platform aims to provide robust and durable immune responses by encoding antigens in a stable RNA format, delivered via LNPs. The primary developer and manufacturer is Therorna, with initial development by Yuanyin (Beijing) Biotechnology. As of early 2024, TI-0010 is in Phase 1 clinical trials evaluating its safety, tolerability, and immunogenicity in healthy adults aged 18–59[1][2][3][4].
02
Targets
RBD (SARS-CoV-2 spike receptor-binding domain)
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