TI-16

TI-16: sourced facts only. name: "Here, we report the identification and mechanistic characterization of TI-16, a novel small-molecule inhibitor of TNF-α-TNFR1 interaction, discovered through structure-based virtual screening and validated by biophysical and cellular assays." [PMID:41571205]; target: "Here, we report the identification and mechanistic characterization of TI-16, a novel small-molecule inhibitor of TNF-α-TNFR1 interaction, discovered through structure-based virtual screening and validated by biophysical and cellular assays." [PMID:41571205]; developer: "Department of Molecular Science and Technology, Ajou University, Suwon 16499, South Korea; S&K Therapeutics, Ajou University Campus Plaza 418, Worldcup-ro 199, Yeongton-gu, Suwon 16502, South Korea." [PMID:41571205]; modality: "Here, we report the identification and mechanistic characterization of TI-16, a novel small-molecule inhibitor of TNF-α-TNFR1 interaction, discovered through structure-based virtual screening and validated by biophysical and cellular assays." [PMID:41571205]; stage: "TI-16 effectively protected fibroblasts from TNF-α-induced apoptosis and necroptosis and reduced the release of proinflammatory cytokines." [PMID:41571205]