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tian wang bu xin dan

Development stage: Phase 2
Lead developer: Chung Shan Medical University
Administration: Oral, Transdermal

Overview

Tian Wang Bu Xin Dan (Heavenly King Tonify the Heart Pill) is a classic Traditional Chinese Medicine (TCM) formula dating back to the Ming Dynasty. It is composed of approximately 13 herbs, including *Rehmannia glutinosa*, *Salvia miltiorrhiza*, and *Ziziphus jujuba*, designed to treat 'Heart and Kidney Yin deficiency.' Clinically, it is used to manage insomnia, anxiety, palpitations, and cognitive decline. Modern research suggests its sedative effects are mediated through the modulation of GABAergic and serotonergic pathways. It is currently being evaluated in clinical trials for primary insomnia, perimenopausal syndrome, and the prevention of postoperative delirium in elderly patients.

Brand names: Tian Wang Bu Xin Dan
Other names: Tian-Wang-Bu-Xin-DanTianwang Buxin DanEmperor's Tea to Enrich the HeartHeavenly King Tonify the Heart PillTianwang Buxin GranuleTianwang Buxin DecoctionModified Tian Wang Bu Xin Dan

Targets

GABA-B (Gamma-aminobutyric acid receptor type B)5-HT (Serotonin receptors)

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