Tianjin Univ. of Science and Technology PPARγ compound 2d

Tianjin Univ. of Science and Technology PPARγ compound 2d: sourced facts only. name: "this study integrated structural features of GFT505-3d and ZLY06 to develop two novel compounds: the pan-PPAR agonist 1d and the PPARγ agonist 2d." [PMID:41075607]; target: "this study integrated structural features of GFT505-3d and ZLY06 to develop two novel compounds: the pan-PPAR agonist 1d and the PPARγ agonist 2d." [PMID:41075607]; developer: "China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science and Technology, Tianjin, 300457, China." [PMID:41075607]; stage: "In HFD/STZ-induced type 2 diabetes mellitus (T2DM) models, 1d and 2d improved insulin resistance and hepatic lipid metabolism by suppressing PPARγ Ser273 phosphorylation in white adipose tissue and upregulating insulin-sensitizing genes such as adiponectin, without causing weight gain or fluid retention typically associated with conventional PPARγ agonists." [PMID:41075607]