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Tianlong Kechuanling
- Development stage
- Unknown
- Lead developer
- Gansu Provincial Hospital of Traditional Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Tianlong Kechuanling (TL) is a Traditional Chinese Medicine (TCM) compound hospital preparation primarily utilized in clinical practice for the treatment of pulmonary heart disease (cor pulmonale) and its complications, such as chronic obstructive pulmonary disease-associated pulmonary hypertension (COPD-PH). Administered as a decoction, TL has been shown to improve pulmonary function and reduce right ventricular systolic pressure (RVSP) and hypertrophy. Its therapeutic mechanism involves the inhibition of endothelial cell pyroptosis by targeting the DNMT3A-GSDMD signaling pathway and the attenuation of pulmonary hypertension by suppressing endothelial-to-mesenchymal transition (End-MT) via the HIF-1α/VEGFA pathway. Additionally, it modulates inflammatory responses by reducing levels of pro-inflammatory cytokines including TNF-α, IL-1β, IL-6, and IL-18.
- Brand names
- Tianlong Kechuanling
- Other names
- Tianlong Kechuanling decoction天龙咳喘灵
02
Targets
HIF1A (Hypoxia-inducible factor 1-alpha)VEGFA (Vascular endothelial growth factor A)DNMT3A (DNA methyltransferase 3 alpha)GSDMD (Gasdermin D)
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