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Tiao-Chang Ke-Min Granules

Development stage: Unknown
Lead developer: The Second Affiliated Hospital of Guangzhou University of Chinese Medicine
Modality: Small Molecules
Administration: Oral

Overview

Tiao-Chang Ke-Min Granules is a Traditional Chinese Medicine (TCM) hospital preparation developed by the Second Affiliated Hospital of Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine) for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D). The formula is designed to regulate the spleen and liver, alleviate abdominal pain, and stop diarrhea. It likely acts by modulating the brain-gut axis, reducing visceral hypersensitivity, and regulating intestinal motility and mucosal barrier function. Clinical studies have evaluated its efficacy in improving symptoms such as abdominal pain, bloating, and stool consistency in patients with IBS-D. The preparation is based on classical TCM principles and typically includes a combination of herbs such as *Atractylodes macrocephala*, *Paeonia lactiflora*, and *Citrus reticulata*.

Brand names: Tiao-Chang Ke-Min granules
Other names: Tiaochang Kemin GranulesTiaochang Kemin KeliTiao-Chang Ke-Min

Targets

PAR2 (Protease-activated receptor 2)5-HT (Serotonin receptors)

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