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Tiaochang Xiaoyan Pian
- Development stage
- Phase 1
- Lead developer
- Guangzhou University of Chinese Medicine
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Tiaochang Xiaoyan Pian (TCXYT) is a traditional Chinese medicine (TCM) botanical formulation derived from the classical Xianglian pill, historically used for the treatment of chronic dysentery. It is primarily investigated for its therapeutic effects in ulcerative colitis and chronic colitis. The drug functions by inhibiting the TLR9/MyD88/IRAK signaling pathway, which leads to the activation of macrophage lysosomes and a subsequent reduction in intestinal inflammation. Research and clinical trials for this formulation are largely driven by institutions such as the Second Affiliated Hospital of Guangzhou University of Chinese Medicine.
- Brand names
- Tiaochang Xiaoyan tablet
- Other names
- Tiaochang Xiaoyan tabletTiaochang Xiaoyan extract tabletTCXYT调肠消炎片
02
Targets
IRAK4 (Interleukin-1 receptor associated kinase 4)MYD88 (Myeloid differentiation primary response protein MyD88)TLR9 (Toll-like receptor 9)
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