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Tiaopi Anchang Decoction
- Development stage
- Unknown
- Lead developer
- China-Japan Friendship Hospital
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Tiaopi Anchang Decoction (TPACD) is a Traditional Chinese Medicine (TCM) oral formula composed of edible botanical drugs, developed for the treatment of colorectal cancer (CRC). It is primarily utilized as a complementary therapy in combination with standard adjuvant chemotherapy, such as the CAPOX regimen (capecitabine and oxaliplatin), for patients with stage III or high-risk stage II CRC. Clinical studies, including a randomized, double-blind, placebo-controlled trial (ChiCTR2200065759), have demonstrated that TPACD significantly improves disease-free survival (DFS), reduces chemotherapy-induced adverse reactions, and enhances the quality of life for patients. The decoction is administered orally and is thought to work through multi-target modulation of the body's internal environment to prevent recurrence and metastasis.
- Other names
- TiaoPi AnChang Decoction
02
Targets
AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)EGFR (Epidermal growth factor receptor)ESR1 (ERα)HIF1A (Hypoxia-inducible factor 1-alpha)MAPK14 (p38 mitogen-activated protein kinase alpha)MMP2 (Matrix metalloproteinase-2)MMP9 (Matrix metalloproteinase-9)SRC (Proto-oncogene tyrosine-protein kinase Src)
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