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ticagrelor + morphine + metoclopramide
- Development stage
- Phase 4
- Lead developer
- AstraZeneca
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
This is a combination of three medications used in acute coronary syndrome patients. Ticagrelor is an oral P2Y12 inhibitor antiplatelet medication, morphine is an opioid analgesic, and metoclopramide is a prokinetic agent. The combination addresses the known interaction between morphine and ticagrelor, where morphine delays the absorption and onset of action of ticagrelor. Metoclopramide is co-administered to overcome this delay by increasing gastric emptying and improving the pharmacokinetics and pharmacodynamics of ticagrelor.
02
Targets
HTR4 (5-Hydroxytryptamine receptor 4)DRD2 (Dopamine D2 Receptor)ENT1 (Solute carrier family 29 member 1)P2Y12 (Purinergic P2Y12 receptor)ADCYAP1R1 (Pituitary adenylate cyclase-activating polypeptide receptor PAC1)VIPR1 (Vasoactive intestinal peptide receptor 1)VIPR2 (Vasoactive intestinal polypeptide receptor 2)DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)MOR (Mu opioid receptor)HTR3A (5-hydroxytryptamine receptor 3A)
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