ticarcillin

Ticarcillin is a semisynthetic, extended-spectrum carboxypenicillin antibiotic belonging to the beta-lactam class. It is primarily used for the treatment of moderate-to-severe infections caused by susceptible Gram-negative bacteria, especially Pseudomonas aeruginosa and Proteus vulgaris. Its mechanism of action involves inhibition of bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), thereby preventing cross-linking of peptidoglycan chains during cell division, which leads to bacterial cell lysis and death. Like other penicillins, it contains a β-lactam ring that can be hydrolyzed by β-lactamases produced by resistant bacteria[1][2][3][5]. Ticarcillin is not absorbed orally and must be administered intravenously or intramuscularly[3]. It has also been used in molecular biology as an alternative to ampicillin for selection purposes due to its stability in culture media[3].

Brand names

Ticar

Other names

TicarcilinaTicarcillineTicarcillinumα-carboxy-3-thienylmethylpenicillin