Tie2-Fc

Tie2-Fc is a recombinant chimeric decoy receptor designed to inhibit the angiopoietin/Tie2 signaling pathway. It consists of the extracellular domain of the Tie2 (tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2) receptor fused to the Fc region of a human immunoglobulin (IgG). Tie2-Fc acts as a molecular trap by binding to and sequestering circulating angiopoietins, including Ang-1, Ang-2, and Ang-4, thereby preventing them from interacting with the endogenous Tie2 receptors located on the surface of endothelial cells. This blockade suppresses pathological angiogenesis, vascular remodeling, and associated inflammatory processes. In preclinical research, Tie2-Fc has been utilized to study and treat conditions characterized by abnormal vessel growth and inflammation, such as rheumatoid arthritis and various solid tumors, where it helps reduce synovial inflammation, macrophage infiltration, and bone destruction.

Other names

Tie2-Fc fusion proteinTie-2-Fc fusion proteinTie 2-Fc fusion proteinTie2 decoy receptorTie-2 decoy receptorTie 2 decoy receptorSoluble Tie2-Fc