Drug intelligence / Profile preview

tieghemella heckelii hydroethanolic leaf extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Oral
01

Overview

Tieghemella heckelii hydroethanolic leaf extract is a botanical preparation derived from the leaves of the *Tieghemella heckelii* tree, commonly known as Baku or Cherry Mahogany, which is indigenous to the rainforests of West and Central Africa. While the plant's stem bark has a history of traditional medicinal use, recent scientific investigation has pivoted toward the leaves to evaluate their therapeutic potential. Research indicates that the hydroethanolic extract possesses significant in vitro cytotoxic properties against several human malignancy models, including breast cancer (MDA-MB-468), liver cancer (HepG2), and prostate cancer (PC3) cell lines. The extract is thought to contain bioactive phytochemicals that interfere with cancer cell viability, although the specific molecular pathways and active constituents responsible for these effects are still under investigation in the preclinical stage.

Other names
Tieghemella heckelii leaf extractBaku leaf extract
02

Targets

NMDAR (Glutamate receptor ionotropic, NMDA)

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