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TIGR4-Fc
- Development stage
- Preclinical
- Lead developer
- Alebund Pharmaceuticals
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Therapeutic Enzymes → Recombinant Proteins and Enzymes
01
Overview
TIGR4-Fc is a preclinical-stage recombinant fusion protein consisting of a truncated IgA protease derived from *Streptococcus pneumoniae* strain TIGR4 fused to an immunoglobulin Fc domain. Developed by Alebund Pharmaceuticals in collaboration with Northwestern University Feinberg School of Medicine, TIGR4-Fc is designed for the treatment of IgA nephropathy (IgAN). The IgA protease specifically cleaves the hinge region of human IgA1 heavy chains, thereby clearing pathogenic IgA and IgA-containing immune complexes deposited in the glomerular mesangial area of the kidneys. The fusion with the Fc domain extends the plasma half-life of the protease, allowing for sustained in vivo efficacy.
- Other names
- recombinant TIGR4-FcTIGR4-IgG1 FcTIGR-4-IgG1 FcTIGR 4-IgG1 Fc
02
Targets
IgA1 (Immunoglobulin heavy constant alpha 1)
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